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The suppression of the type I IFN response by ROS is due to oxidation of cysteine 147 of murine stimulator of IFN, an ER membrane protein that mediates the IFN response after cytoplasmic DNA sensing 59,133,134
Additionally, It can inhibit cell proliferation and reduce colony formation in both standard cell culture and soft agar assays, which are commonly used to assess tumorigenic potential 9
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