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Exercise intolerance is evident in DOCA-salt mice after TAC ( 2.1.4 Dahl salt-sensitive rats (H 2 FPEF score 4) This strain of salt-sensitive Sprague-Dawley rats is only genetically distinguishable from the salt-resistant Dahl rat strain by a polymorphism in the renin gene ( 2.1.5 Spontaneous hypertensive rats (H 2 FPEF score 4) Originally used to model essential hypertension in human, this inbred strain of rats develops concentric LV hypertrophy with preserved systolic function ( 2.2 Aging According to the Framingham Heart Study and Baltimore Longitudinal Study on Aging, aging positively correlates with prevalence of LV hypertrophy, even in the absence of hypertension

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Rawson RA, Marinelli-Casey P, Anglin MD, Dickow A, Frazier Y, Gallagher C, et al , Methamphetamine Treatment Project Corporate Authors (2004)