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Some early references also described the function of GSTs in regulating the activity of kinases such as ASK1 via protein-protein interactions 14,44,45,46
However, GS-4997 completely inhibits the activity and normal function of ASK1 with potential side effects 41,42
Additionally, it effectively improves immune function,
A separate 2024 meta-analysis (Alshammari et al.) confirmed the same conclusion, further strengthening the evidence base
