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The trial product estimand assumed participants adhere to their assigned treatment during the trial

What NOT to expect in the first 3 nights: Sedation (DSIP is not a sedative a drugged or groggy feeling is a signal to check the dose) Complete resolution of chronic insomnia (sleep architecture remodeling takes longer) Stress or cortisol changes (HPA axis modulation requires sustained dosing) Administration timing: Community protocols describe subcutaneous DSIP 30-60 minutes before the intended sleep time

That was the test period

Research has demonstrated that fMRI can detect alterations in brain activity patterns that correlate with cognitive deficits