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The conversion of glutamate to proline begins with the activation of glutamate by -glutamyl kinase (the first enzymatic activity of the bifunctional pyrroline-5-carboxylate synthase, P5 CS), which uses ATP to phosphorylate glutamate to -glutamyl phosphate [15]
In summary, pharmacological strategies targeting BA signaling offer a diverse toolkit to reshape the TIME and influence cancer immunity

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