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It should be noted that a related molecule, ()-physostigmine (5), can cross the bloodbrain barrier
C.FazioA.La TorreC.PlastinaP.GallelliL.et al (2019)

doi: 10.1097/MCG.0000000000001236 Artin Galoosian , Mona Rezapour, Benny Liu, Taft Bhuket, Robert J Wong
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