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Avoiding habits like lip licking, smoking, or irritants can avoid further darkening
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However, it is likely that the high serum ferritin observed in other cancers may be a generic cancer characteristic that is applicable to all brain cancers

217 Autophagy-related proteins such as p62 and transcription factor EB (TFEB) are linked to GBM prognosis, with high p62 expression correlating with PS and tumor recurrence
