pnb0408 dihexa (also known as PNB-0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the blood–brain barrier and has shown synaptogenic effects in preclinical models. The often-quoted Dihexa - Wikipedia

"Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial." Annals of Internal Medicine

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Absorption of vitamin B 12 is inhibited from both dietary sources and from the bile (enterohepatic circulation) and thus depletion of vitamin B 12 body stores can occur relatively quickly