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During the process of neurodegeneration, it is likely that excess cholesterol was converted into 24S-OHC in the neurons, leading to the up-regulation and increased expression of ApoE proportionally to the amount of neurodegeneration (Leoni and Caccia, 2011)

PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression

Furthermore, the high cost of these therapies remains a barrier to widespread access, particularly for patients in underserved populations

Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay