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doi:10.1097/PRS.0000000000005707 Halaas Y, Duncan D, Bernardy J et al

The treatment was well tolerated, with no adverse events or clinically meaningful changes observed in vital signs, electrocardiograms, or laboratory biomarkers assessing cardiac, hepatic, renal, thyroid, or metabolic function

Third, the discovery that MOTS-c also plays roles in immune regulation, particularly in suppressing innate immune overactivation, has opened research directions in inflammation-driven aging, autoimmunity, and potentially long-term sequelae of infections

For shoulder injuries in low-vascular regions like the rotator cuff, this effect proves particularly valuable