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The deficit of GSH may result in a type of cell death called ferroptosis. The application of an iron chelator almost completely reverses ferroptosis which can be explained by the prevention of intralysosomal iron accumulation and leads to the suppression of induced oxidative stress permeabilization of lysosomal membranes (Homma and Fujii, 2015)
Associated neurological disorders Manganism is a neurological disorder associated with elevated blood Mn and Mn deposition in the globus pallidus, most commonly due to environmental exposure
