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Rouzer, C

Regarding the catalytically advantageous nature of Sec, studies of Cys-substituted murine GPx-1 indicate that in the context of mammalian Sec-containing GPxs, the Sec active site may have the added advantage of being less sensitive to overoxidation and inactivation in the presence of peroxides compared to Cys (309)

The Nrf2-dependent adaptive response, which includes phase II detoxifying enzymes, antioxidants, and transporters that protect cells from further carcinogenic assaults, is how chemopreventive substances or synthetic chemicals carry out their chemopreventive action

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