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Mitochondrial dysfunction is recognized as one of the primary hallmarks of biological aging, and MOTS-c directly addresses this mechanism

5-Amino-1MQ formally 5-amino-1-methylquinolinium iodide is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT)

The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

Adv Ther 36 , 29862996 (2019)