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The UL was established for generally healthy people, and the FNB noted that individuals with liver or kidney disease, Parkinson's disease, depression, or inherited trimethylaminuria might be at increased risk of adverse effects when consuming choline at levels near the UL (32)
TMAO (or trimethylamine N-oxide) is a metabolite produced by gut bacteria
Another limitation is that DMPD is soluble only in water, making it unsuitable for hydrophobic antioxidants (Fogliano et al
It performs its primary function in fat metabolism (as a transporter of fatty acids)
