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Furthermore, using FR to better localize effective anticancer therapies to their target tumours using platforms such as antibodydrug conjugates, small-molecule drug conjugates, radioimmunoconjugates and, more recently, chimeric antigen receptor T cells could further improve the outcomes of patients with FR-overexpressing cancers

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These alterations drive transcriptional reprogramming, impair mitochondrial quality control, and amplify neuroimmune signaling

doi: 10.1177/1073858421992265 88 LercheS.WursterI.RbenB.ZimmermannM.MachetanzG.WiethoffS.et al