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The mPTP plays dual roles in cell survival and death, depending on the duration and extent of opening: transient openings participate in the physiological regulation of calcium homeostasis, bioenergetics, and redox balance, whereas sustained opening leads to mitochondrial swelling, outer membrane rupture, and subsequent apoptotic and necrotic death, which are important in various diseases

Prenatal exposure to gestational diabetes mellitus, which may expose the foetus to chronic inflammation, also increases the risk of ADHD [175], reinforcing the potential effects of maternal inflammation on child neurodevelopment

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A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells