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[7] Unlike capsaicin, 6-paradol produces sustained thermogenic effects without receptor desensitization, making it effective for repeated daily use

Cardiologia 1990;35(7):591-596

Loss of Ozz or Alix in vivo disrupts the steady-state levels of Slc25A4, impairing mitochondrial metabolism and triggering a switch in muscle fiber composition from oxidative, mitochondria-rich slow to glycolytic fast fibers
