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Reported side effects have mostly been mild: transient injection-site reactions, occasional headaches, or mild flu-like symptoms

Future studies should deal with the impact of this approach in different tumour sites and their secondaries, address the wide variations in tumour behavior caused by intratumor heterogeneity and focus on the potential complications of promoting neovascularization, such as the risk of significant/life threatening bleeding, and its safety in vascular diseases

This class of inhibitors has been recently developed, thus there is a scarcity of reported cellular or in vivo data concerning these compounds