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Similar content being viewed by others Introduction Stress-induced premature senescence (SIPS), a kind of replicative senescence due to depletion of cell proliferative potential, is caused by a variety of sublethal stresses, such as H 2 O 2 , hypoxia, or hyperoxia 1

EGR1, predominantly located in the nucleus, is involved in crucial processes including cell proliferation, growth, apoptosis and ferroptosis through various signaling pathways [14, 15]

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doi: 10.1128/JCM.00832-08