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Ablation of all NR4A members prevents terminal exhaustion of CD8 T cells, resulting in the replacement of exhausted cells with effector-like T cells characterized by low PD-1 and Tim-3 expression [44]

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Chen J., Wang M., Wang M., et al., Synthesis and Biological Evaluation of Geniposide Derivatives as Inhibitors of Hyperuricemia, Inflammatory and Fibrosis, European Journal of Medicinal Chemistry 237 (2022): 114379, 10.1016/j.ejmech.2022.114379

GH secretion peaks at puberty and declines with age roughly half of peak by the forties and lower still by the sixties a normal physiologic process sometimes called somatopause