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The prolonged EMD in the quadriceps and hamstrings suggests that these muscles are less effective at counteracting anterior tibial translation and rotational forces, placing greater stress on the passive structures of the knee, including the ACL graft or remaining ligamentous tissue

Some general physical modalities and measures that may be helpful include the following: Diathermy to chest and back: 30 min/day Mustard poultice: once/day Lymphatic massage: three times a day Postural drainage: three times a day Bottle-blowing therapy: blowing bubbles in a bottle containing 10 mL water through a plastic tube 20 times on 10 occasions a day Getting plenty of rest Drinking enough liquids Using a humidifier Expectorants Choose one or more of the following: Lobelia inflata Dried herb: 50 to 200 mg three times a day Tincture: 10 to 20 drops three times a day Fluid extract: 8 to 10 drops three times a day Glycyrrhiza glabra Powdered root: 1 to 2 g three times a day Fluid extract (1:1): 2 to 4 mL (0.51 tsp) three times a day Solid (dry-powdered) extract (4:1): 250 to 500 mg three times a day Pelargonium sidoides Dosage recommendations for EPs 7630 or equivalent preparation are as follows: Adults: 1.5 mL three times a day or 20-mg tablets three times a day for up to 14 days Children: age 7 to 12 years, 20 drops (1 mL) three times a day

This approach enables truly site-specific, stoichiometric PEGylation that yields a homogeneous product with simplified analytical characterization and regulatory documentation