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Toxin and drug exposure Some also hypothesise that toxin exposure could trigger ME/CFS (61), such as organophosphate compounds (152, 153) and heavy metals (154)

The activation of these pathways can also induce the production of growth factors, such as TGF-beta and IGF-1, which promote fibroblast proliferation and collagen synthesis, enhancing the strength and repair capacity of the ligament

1 2 "Office of Dietary Supplements - Dietary Supplement Fact Sheet: Vitamin B12"