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Symptoms can include headache, nausea, vomiting, fatigue, and sensitivity to light and noise. Long-term effects of alcohol Alcohol dependence:Alcohol dependence is a chronic condition that can lead to physical and psychological addiction. Liver disease:Alcohol is toxic to the liver

For in silico analysis, we screened two public datasets, GSEA M5190 and TCGA SARC

To provide quantitative data on the possible role of HNE in oxidative genotoxicity, we applied an accurate HPLC-MS approach to the quantification of HNE adducts to DNA and of HNE conjugates to glutathione (HNE-GSH), the product of the major detoxification pathway of HNE in cells