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To emphasize the non-neoplastic nature of oral MA, Tomich & Zunt (6) suggested the term melanoacanthosis
From a therapeutic standpoint, berberine inhibits SREBP-1c transcriptional activity by activating AMPK-mediated phosphorylation, thereby downregulating target genes such as SCD1

10.1038/aps.2009.155 Acta Pharmacol

Trinidad Montero-Melendez has previously received research funding and conducted consultancy for SynAct Pharma ApS
