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P38, extracellular signal-regulated kinase (Erk), and Jun N-terminal kinase (JNK) are the family of mitogen-activated protein kinase (MAPK)[104, 105]

To understand whether the GLP-1MK-801 conjugate activates distinct neural circuitries, we used light-sheet microscopy and cFOS immunohistochemistry to obtain quantitative 3D whole-brain activity signatures in response to GLP-1MK-801 and semaglutide dosing (Fig