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Early human trials in people with obesity found that daily AOD9604 was well tolerated and had a safety profile similar to placebo, with no major effects on glucose metabolism or IGF1, though weightloss results were modest and inconsistent

The intellectually honest bottom line is that the compounds acute pharmacology matches the title well, its chronic gastric-emptying behavior is a genuine open question, and its postprandial-metabolism effects are real in principle but partly entangled with its combination partner in the clinic

This strategy allowed invasive local delivery to an extremely small extent