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141,142,143 With respect to ALS, mutations in the SOD1 gene (which encodes Cu/Zn superoxide dismutase, a physiologically important Cu-binding protein) are the principal cause of the familial form of ALS
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86 In this model, CLP induced PMN infiltration in the peritoneal cavity, the site of infection, as well as in the lung, ultimately resulting in lung injury and death, with a concomitant decrease in endogenous GSH
