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4 Discussion The findings indicate that HUVEC exhibit distinct responses when stimulated with serum from patients with severe COVID-19, convalescents, and HV, demonstrating the endotheliums critical role in the bodys reaction to COVID-19

A case study from PvSTATEM Byrne Isabel 1 , Fornace M Kimberly 2 , Emiru Tadele 3 , Mangahasimbola Tiandraza Reziky 4 , Demisse Mulugeta 3 , Abdo Melat 3 , Fikregabrail Aberra Kassa 3 , Bulto Mikiyas 3 , Rakotomanana Fanjasoa 4 , Randrianarisoa Malala Mirella 4 , Obadia Thomas 5 , Van der Pluijm Robert 5 , Randremanana Rindra 4 , Tadesse Fitsum 3 , White Michael 5 , Drakeley Chris 1 1 Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

42 Ferroptosis is initiated by the depletion of GSH, leading to the inactivation of GPx4, a key enzyme that protects against lipid peroxidation