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The Nrf2-Keap1 Pathway: Structure, Mechanisms, and Regulation The molecular architecture of Nrf2-Keap1 reflects its critical role in oxidative stress regulation

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As a result, upregulation of NRF2 target genes resulted in growth advantages and cisplatin resistance of lung cancer cells.17 Although the nature of NRF2 mutations, which involve direct DNA changes, results in loss of affinity for binding to the KELCH region, the KEAP1 mutations create steric hindrance and gross structural changes in the formation of the NRF2:KEAP1 complex

The effect of radiation treatment of solid tumors on neutrophil infiltration and function: a systematic review