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Opioids should be suggested on first approach 7

Lancet Psychiatry

261 In an uncontrolled trial in 47 subjects with fibromyalgia, 400 mg of oral SAMe twice daily plus 200 mg of intramuscularly injected SAMe once daily for six weeks decreased tenderness, increased general well-being, and improved scores measuring depression, anxiety, and mood

Assessment of adipose tissue metabolism in man: comparison of Fick and microdialysis techniques
