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Description
Its mechanism of action is due to the fact that it assists with maintenance of intestinal mucosal integrity, modulation of inflammatory response, nucleotide biosynthesis, energy metabolism, and stimulation of immunity (Perna et al., 2018)

Peer review Peer review information Nature Communications thanks Mitsuyasu Hasebe, Hiroaki Mano, Andrej Pavlovic and Michael Wudick for their contribution to the peer review of this work

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Total B12 concentration in serum is most frequently used, despite its poor sensitivity and specificity
