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It is estimated that nearly 1.4 billion adults worldwide (over the age of 18, with 20% of women and 25% of men) have hypertension, with a significant portion of cases undiagnosed [1]

Medical applications become dangerous when non-sterile water is used because it creates serious risks that could prove fatal

Below is an example of introducing non natural amino acids: R1-NH 2 + C 10 H 10 N 2 O 2 -OH C 10 H 10 N 2 O 2 -R1 + H 2 O It should be noted that due to the different structures of the amino acid side chain group R1, the reaction conditions, solvents, reagents, etc

The inhibition profile of methylene blue on nitrovasodilator induced cyclic guanosine monophosphate accumulation was quantitatively reproduced by extracellular generation of superoxide anion with xanthine (100 uM) and xanthine oxidase (5 mU)