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However, since the follow-up time is limited, it is not clear whether these treatments are effective for a long period of time

Maybe it's an issue with a particular insurance company

For example, in the Inflammasome pathway , NLRP1 was inhibited in the MOD group and B12 abrogates this inhibition ( Figure S8 )
meaning if you are functionally deficient in B2, it is highly likely you will also have a B12 functional deficiency