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When drug tolerance sets in, individuals will often experience an uncontrollable urge to obtain more substances

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Russo et al ., 1999), 2) direct genotoxic effects through metabolic activation of estrogens (Liehr, 1998

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However, Hinge did effectively inhibit spine formation in neurons stimulated with 10 ng/ml HGF (Figure 13B), 10 " 12 M Nlel-AnglV ( Figure 13C) or lO "12 M Dihexa ( Figure 12D) further supporting the contention that these actions are mediated by the HGF/c- Met system

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