5-AMINO 1MQ
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Description
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Decoupling the assay by first starting the transaminase reaction followed by addition of the dehydrogenase did not alter overall velocities concluding that the dehydrogenase reaction must be the rate limiting step in the reaction
Specific PHGDH inhibitors exhibit lower toxicity and a wider therapeutic window by targeting tumor-specific modification sites (135)
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