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Kurtz et al., 1987)
Endostatin is a physiological signal molecule produced by the proteolytic cleavage of collagen XVIII
The PIONEER 8 study demonstrated the efficacy of once-daily oral semaglutide as an add-on to insulin therapy in people with T2D who were uncontrolled on insulin (with or without metformin)
The samples were then homogenized (Pellet Pestle motor, Kontes) and centrifuged at 4500 g for 15 min at 4C
