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In addition to ATP-mediated mechanisms, direct interactions between sensory nerve endings and immune cells further modulate both inflammation and healing: activation of nociceptors results not only in pain transduction but also in release of neuropeptides that regulate the activity of macrophages and other myeloid cells, influencing wound closure and tissue repair [46,47,48]

If you have any doubts about the integrity of the medication (for instance, if it changed color or appearance, or was inadvertently left out), err on the side of caution and consult your healthcare provider or pharmacist for advice