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In summary, mitochondrial dynamics are critical for maintaining mitochondrial functionality and mitigating cellular aging
The GSH:GSSG ratio ranges from 50:1 to 200:1 and is maintained by the glutathione reductase Gor, dependent on the cellular NADPH-pool (slund et al., 1999
Neuroreport 9(6):11911193 Corti C, Battaglia G, Molinaro G, Riozzi B, Pittaluga A, Corsi M, Mugnaini M, Nicoletti F et al (2007) The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection
When glutathione levels drop in the brain, neuroinflammation increases, impairing neurotransmitter function and slowing cognitive processing speeds
