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Antioxidant therapies and oxidative stress in Friedreichs ataxia: the right path or just a diversion

HarrisonSARinellaMEAbdelmalekMFTrotterJFParedesAHArnoldHLet alNGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

575 Similarly, the loss of mitochondrial complex I leads to a decrease in the ratio of NAD + /NADH and can inhibit the activity of Sirt3, thereby enhancing the protein acetylation and mPTP sensitivity

When these two proteins interact they bind to specific PPAR response elements (termed PPREs) in target genes thereby regulating their expression
