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[DOI] [PubMed] [Google Scholar] 82.Ashoori M., Saedisomeolia A

Hasan M, Khatun A, Fukuta T, Kogure K

[41] showed that edaravone dexborneol effectively suppressed nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) inflammation-induced activation of microglial pyroptosis in experimental ischemic stroke through NF-B/NLRP3/gasdermin D (GSDMD) signaling pathway using transient MCAO (tMCAO) mouse model in vivo and oxygen-glucose deprivation (OGD) BV2 cell model in vitro

Finally, it is important to note that hotspot TP53 missense mutations might have a distinct impact on the pathophysiology of cancer cells from that of truncating mutations or homozygous deletions which lead to absence of functional protein 59,61 , underscoring an additional layer of nuance when considering the role of tumor suppressor genes in PDAC