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44 The corticotropin (ACTH) stimulation test is used to diagnose a variety of adrenopathic conditions, including endogenous or iatrogenic hyperadrenocorticism, as well as spontaneous hypoadrenocorticism.42, 45, 46 As a screening test for the diagnosis of naturally occurring hyperadrenocorticism, the ACTH response test has a diagnostic sensitivity of approximately 80% to 85% and a higher specificity than the LDDS test.45, 46 In a study by Kaplan and Peterson, only 15% of dogs with nonadrenal disease exhibited exaggerated response to ACTH stimulation

Its primary function is to stimulate the body's own pituitary gland to naturally produce and secrete more human growth hormone (HGH)

Further, induction of toxicity by TVX resulted in loss of the organotypic trabecular arrangement of differentiated hepatocytes and a subsequent change towards an elongated morphology