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Vitamin E (-tocopherol) is found in the cell membrane of the oocyte and is evidently the first line of defense recruited to disrupt the chain of fatty acid peroxidation protecting the oocyte from further oxidative damage [92]

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Discussion In the present study, we provide new evidence that oxidative stress induced by organic oxidants primarily causes ferroptotic cell death in cardiomyocytes, highlighting the significance of this new cell death modality in heart disease driven by elevated oxidative stress