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These compounds act by scavenging reactive oxygen species and inducing endogenous antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) [9]

these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

Diethylmaleates mechanism of action involves the disruption of disulfide bonds, leading to conformational changes in proteins and altering their activity

doi: 10.1016/j.cbpa.2008.01.021
