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Risk of Lymphoma Associated with Anti-TNF Therapy in Patients with Inflammatory Bowel Disease: Implications for Therapy

The AIF pathway, together with increased levels of cleaved caspase 3, is recognized as the main inductor of apoptosis in the damaged brain of neonatal rodents 38 , even if their action becomes less pronounced once the brain matures 39

This process thereby downregulates the NF-B pathway, augments Treg differentiation, and suppresses Th17 expansion and inflammatory cytokine release (215, 216)

doi: 10.1159/000199335
