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FBW7 has been shown to regulate lipid peroxidation and enhance ferroptosis in pancreatic cancer and to inhibit stearoyal-CoA desaturase (SCD1) activity [57]
2020 Aug 8/4/2020
Consistently, in patients with mutations in the N-acetyl transferase ( NAT ) gene, which is involved in the metabolism and detoxification of free radical species, age-related hearing loss occurs more frequently than in healthy subjects [24]
Depriving tumours of extracellular glutathione or inhibiting its breakdown is potentially a viable therapeutic strategy for cancer patients, the authors state
