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Interestingly, many patients who relapse on tamoxifen therapy will respond to different types of hormonal manipulation including either ER downregulators/ER angatonists or aromatase inhibitors (AIs), implying that ER continues to play a major role in breast cancer progression (Pike et al ., 1993

In 1975, in a medical school classroom in what was then the Socialist Federal Republic of Yugoslavia, Predrag Sikiric had an idea that he has pursued for more than 50 years

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Conclusions Our theoretical and conceptual analysis of allosteric mechanisms emphasizes allosteric networks and signaling bias