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On July 22, 2022, the FDA proposed a new rule to update the NDC, or National Drug Code, format from a 10-digit code to a 12-digit code over the next five years citing that the NDC will eventually run out of 5-digit labeler codes within the next 10 to 15 years.

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This outcome was attributed to MOTS-c restoring metabolic balance in muscle tissue (largely via AMPK activation), underscoring its potential for combating age-dependent metabolic decline
