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Despite the complexity of TMAOs role in atherosclerosis, studies have indicated that managing TMAO through nutrition, medication, or microbiome modification may help lessen its effects and even reverse its contribution to the advancement of the disease [73, 76]

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The lipidomics profiling analysis of bison samples identified a total of 1032 compounds with 393 (38%) of identified compounds being different ( P 0.05) between the pasture- and pen-finished bison striploin samples (Additional file 3: Table S2)

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