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GHK-Cu: The Science Behind the Copper Peptide Transforming Skin Repair and Regeneration
doi:10.1016/j.exger.2014.12.016 Gebara KS, Gasparotto Junior A, Palozi RAC, et al

Topical application must penetrate the skin barrier, and even the best formulations lose a significant portion of the active compound during that process

Acute kidney injury previous investigations have demonstrated that administering gentamicin to rats results in glomerular expansion, uneven thickening of the glomerular basement membrane, and neutrophil infiltration, as proven by microscopy 86