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Steroid injections may produce local reactions, occurring most often immediately after injection

In fact, transplanting senescent cells into mice knee joint has been found to induce an osteoarthritis-like change (Xu et al., 2017)

Jo SJ, Shin H, Park YW, Paik SH, Park WS, Jeong YS, Shin HJ, Kwon O (2014) Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis

However, an observational study reported a dramatic increase in the risk of post-renal transplant dementia after a 10-year follow-up (115)